To help you get the most for your money and truly obtain the benefits you’re seeking from an Ear Health supplement, Nature’s Essentials uses Cyclosome™ liposomal delivery technology designed to first create a vortex of solubility with the effective but hydrophobic and poorly absorbed ingredients, then preserve the active ingredient as it goes through the body resulting in a higher absorption and bioavailability. † This one-of-a-kind technology involves the entrapment of hydrophobic ingredients, like Bioflavonoids, in the form of water-soluble alkaloid–cyclodextrin (CD) complex in liposomes which has been investigated as a new strategy to combine the relative advantages of CDs and liposomes into one system, namely active ingredient-in-CD-in-liposome systems called Cyclosomes™. You can think of all this in terms of a ‘Trojan Horse,’ passing through the harsh acids in the stomach and then through the liver unharmed and intact. As opposed to being destroyed in the stomach and liver like other products on the market, past and present. This new Cyclosome™ technology allows the ‘Trojan Horse’ to deliver the CoQ10 to the systemic circulation by the intestinal lymphatic route, circumventing first-pass inactivation in the liver for the very first time. Almost all previous oral capsules and tablets manufactured to deliver natural alkaloids and active ingredients are involved in some sort of damage from the “first pass affect” which often even renders active compounds virtually useless.
Cyclosome™ Technology — the most advanced liposomal delivery technology ever developed for bioavailability – is the answer to getting poorly absorbed compounds like Bioflavonoids into the body so they can actually work! The pharmaceutical industry has embraced this cutting-edge technology in recent years and now Nature’s Essentials will be one of the first to utilize it for Ear-Rx™ in the Wellness category.
For Cyclosome™ preparation, an overall understanding of the interaction between CDs and lipid components of liposomes is necessary for this complex. Nature’s Essentials has developed a double-loading technique, which is a revolutionary delivery strategy for natural ingredient release and increase active ingredient capacity. The Cyclosome™ approach can be useful in increasing active ingredient solubility and vesicles stability, in controlling the in vivo fate of hydrophobic compounds and in avoiding burst release of active ingredient from the vesicles. To obtain a stable Cyclosome™, the CDs should have a higher affinity to active ingredient molecules compared with liposomal membrane lipids. Cyclosomes™ prepared by Nature’s Essentials’ double-loading technique are the most advanced targeted active ingredient delivery system ever developed because they have a fast onset action with prolonged active ingredient release process and the significantly enhanced active ingredient-loading capacity.
Therefore, don’t wait any longer…your ears will thank you for supplementing with Nature’s Essentials premium Ear-Rx™ with Cyclosome™ delivery technology. †
As always we pride ourselves on the best quality products and value our customers. Each of our ingredients are hand selected for quality assurance, then each product is carefully manufactured under the highest standards for product quality, purity and potency. †
As you already know, Nature’s Essentials is not another “me too” brand. We create our formulas centered around you the consumer and by applying the most cutting edge science and research. For example:

Zinc
Zinc is an essential mineral that is vital for many functions that occur in the body including the support of the immune system, but research is finding that it also protects hair cells in the inner ear. The relationship between zinc deficiency and tinnitus, cochlear damage, and hearing damage has been studied in both humans and animals. Zinc deficiency increases the vulnerability of the cochlea to hearing loss associated with normal aging. Research results indicate that zinc deficiencies increase the vulnerability of the cochlea to damage associated with normal aging. When a zinc supplement was given, one-third of the elderly patients showed marked improvement in tinnitus caused by presbycusis and sensorineural hearing loss. One interesting finding was that researchers found that tinnitus occurred in 13% of children who passed audiometric screening texts, in 23% to 60% of children with hearing loss, and in 44% of children with secretory otitis media. Only 3% of children complain about tinnitus because they do not consider it to be abnormal. According to at least one researcher, tinnitus might be a factor in behavioral problems in children. [Otol Neurotol. 2003 Jan;24(1):86-9. “The role of zinc in the treatment of tinnitus.” Arda HN1, Tuncel U, Akdogan O, Ozluoglu LN.]
Vitamin C
Vitamin C, one of the most widely used vitamins, is a part of the symbiotic mix that has shown results for supporting ear health. In studies, vitamin C proved to be a highly beneficial antioxidant, particularly when combining it with glutathione as a protection against gentamycin ototoxicity. As much as two or three times the normal dosage was recommended during the drug treatment. Vitamin C was also found to help protect or lower the damage to cochlear hair cells and hearing caused by noise exposure. Vitamin C with bioflavonoids has long been used for proper immune function and, as a result, helps in preventing infections, including those in the ears. Nature’s Essentials taking it a step further and including the liposomal Vitamin C helps provide higher serum levels of Vitamin C in lower doses. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Thiamin (B1)
Thiamine not only enhances circulation but also optimizes brain and hearing function. A deficiency is known to produce a delayed auditory brainstem response, so therefore the opposite is also true. A biotin deficiency is also thought to affect development of the auditory nerves. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]
Riboflavin (B2)
Riboflavin B2 is thought to help the hearing cells use needed oxygen. To illustrate how important B2 is as far as the transportation of oxygen is concerned, hyperbaric oxygen treatments are now being recommended as the preferred treatment for sudden hearing loss, acute noise trauma from a car airbag, and Meniere’s disease. Clinical improvement was obtained in eight of the patients. Improvement was observed in the muscle symptoms of easy fatigability, motor disability and severity of stroke-like episodes, as well as in various other symptoms such as phosphate, tinnitus, headache, corneal edema, chilblains, thalamic pain, respiratory failure, and nystagmus. This clinical improvement was maintained for more than 1 year… [Brain Dev. 1997 Jun;19(4):262-7. “Treatment of mitochondrial encephalomyopathy with a combination of cytochrome C and vitamins B1 and B2.” Tanaka J1, Nagai T, Arai H, Inui K, Yamanouchi H, Goto Y, Nonaka I, Okada S.] . [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Niacin (B3)
In the body, niacin is converted into two active forms: NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which are vital in the transfer of energy in cells. They are two of the most important coenzymes in the human cell involved in more than 50 different metabolic reactions. Niacin and its derivatives help nerve and hearing function cells operate at optimal levels by increasing circulation to the ears, as well as other parts of the body. It has been particularly helpful for those suffering from Meniere’s syndrome, associated with hearing loss and vertigo. /// Niacin is a peripheral vasodilator and thus has been used in the treatment of peripheral vascular disorders and migraine headaches. It also has a long history in the treatment of some forms of Meniere’s Disease. Atkinson (1944a) found that about 50 percent of his (selected) patients reported relatively long-term relief from their tinnitus while under chronic maintenance dosages of nicotinic acid – also known as Niacin—injections initially, then oral administration. Flottorp and Wille (1955) used balancing and masking procedures to estimate the magnitude of tinnitus before and during administration of daily nicotinic acid (again, injection initially, oral eventually). As with the Atkinson study, most of the Meniere’s patients reported an improvement in their tinnitus. [“Tinnitus: Facts, Theories, and Treatments.” National Research Council (US) Committee on Hearing, Bioacoustics, and Biomechanics. Washington (DC): National Academies Press (US); 1982.] [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Vitamin B6 (pyridoxine HCl)
According to PubMed, a B6 deficiency can affect peripheral and brainstem auditory pathways. B6 is also thought to be able to help regulate fluid levels in the ears. [J Nutr. 1993 Jan;123(1):20-6. Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats. Buckmaster PS1, Holliday TA, Bai SC, Rogers QR.] [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Vitamin B12
There appears to be a correlation between vitamin B12 deficiency and cochlear function. The level of vitamin B12 in the blood should not be ignored in assessment of auditory function. /// B12 comes in various forms, but the methyl form is the one best used by the body, especially the central nervous system. Cyanocobalamin is the one most often found in nutritional supplements but then has to be converted by the liver. The conversion produces a significantly lesser amount. Therefore, it is best to use the methyl form. A Houston study published in the American Journal of Clinical Nutrition found that deficiencies in both B12 and folate, ones particularly common in the elderly, were likely associated with age-related auditory dysfunction. Deficiencies of these two B vitamins could affect both the nervous and vascular systems associated with hearing. A deficiency has also been associated with chronic tinnitus and noise-induced hearing loss. This led researchers to recommend that serum levels of vitamin B12 be evaluated in persons with tinnitus, noise-induced hearing loss, or age-related hearing loss. A deficiency of B12 may also inhibit myelination (outer covering) of the neurons in the cochlear nerve. Acta Otorhinolaryngol Ital. 2013 Aug; 33(4): 243–247. PMCID: PMC3773962; Effect of vitamin B12 deficiency on otoacoustic emissions R. KARLI, A. GÜL, and B. UĞUR] [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Pantothenic Acid
B5 (Pantothenic acid): Pantothenic acid has been helpful to those suffering from tinnitus where it is thought to ‘coat’ nerve endings in the ear, thereby creating less of the agitating noise. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]
Calcium (as diCalcium phosphate)
choline (this may help in a secondary manner for signaling) Mossy fibers from the spinal trigeminal and dorsal column nuclei terminate in the granule cell domain while en passant boutons from the ganglia terminate in the granule cell domain and core region of the cochlear nucleus. Sources of these somatosensory–auditory projections are associated with proprioceptive and cutaneous, but not nociceptive, sensation. Single unit and evoked potential recordings in the dorsal cochlear nucleus indicate that these pathways are physiologically active. Stimulation of the dorsal column and the cervical dorsal root ganglia elicits short- and long-latency inhibition separated by a transient excitatory peak in DCN single units. Similarly, activation of the trigeminal ganglion elicits excitation in some DCN units and inhibition in others. Bimodal integration in the DCN is demonstrated by comparing responses to somatosensory and auditory stimulation alone with responses to paired somatosensory and auditory stimulation. The modulation of firing rate and synchrony in DCN neurons by somatatosensory input is physiological correlate of somatic tinnitus. bioflavonoids (as lemon bioflavonoids complex with Eridictyol Glycoside) eriodictyol glycoside is a bioflavonoid found naturally in the peel of lemons. [Prog Brain Res. Author manuscript; available in PMC 2008 Oct 13. Prog Brain Res. 2007; 166: 107–123 doi: 10.1016/S0079-6123(07)66010-5; PMCID: PMC2566901; NIHMSID: NIHMS71202, “Neural mechanisms underlying somatic tinnitus” Susan Shore, Jianxun Zhou, and Seth Koehler]

Inositol
Inositol supports the functions that are the basis for a number of signaling and secondary messenger molecules. They are involved in a number of biological processes, including: Insulin signal transduction, Cytoskeleton assembly, Nerve guidance (epsin), Intracellular calcium (Ca2+) concentration control, Cell membrane potential maintenance, Breakdown of fats, Gene expression among others. In Ear-Rx™ inositol supports the movement of the calcium ion into and out of the cytoplasm which functions as a signal for many cellular processes.

Magnesium
Magnesium helps support healthy nerve function in the auditory system, prevents damage to the inner ear hair cells, and protects the arterial linings from physical stress. Studies have shown that this mineral has some protective benefits against noise-induced hearing loss with faster recovery from hearing threshold shift and a significant reduction of trauma caused by high levels of noise exposure, as well as a reduction in ischemia-induced hearing loss. A deficiency did show a significant decrease in these protective benefits. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Ginkgo Biloba
This herb is better known for enhancing the memory, as well as a wide range of other health benefits. This may be because it helps promote blood flow, which works well for the circulation to the ears. It also seems to help to maintain balance in addition to other hearing disorders, including tinnitus, and has been shown to have a protective effect against gentamicin-induced cochlear damage and cisplatin-induced toxicity. GreenMedInfo has a list of abstracts (studies) of nutrients that help hearing loss and substances that affect hearing. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Pine Bark Extract
Pine bark extract contains the alkaloid Pycnogenol (PYC), which studies show is primarily composed of procyanidins and phenolic acids. Procyanidins are biopolymers of catechin and epicatechin subunits which are recognized as important constituents in human nutrition. PYC contains a wide variety of procyanidins that range from the monomeric catechin and taxifolin to oligomers with 7 or more flavonoid subunits. The phenolic acids are derivatives of benzoic and cinnamic acids. The ferulic acid and taxifolin components are rapidly absorbed and excreted as glucuronides or sulphates in men, whereas procyanidins are absorbed slowly and metabolized to valerolactones which are excreted as glucuronides. PYC supports circulation and key elements of blood flow while protecting against oxidative stress in several cell systems by doubling the intracellular synthesis of anti-oxidative enzymes and by acting as a potent scavenger of free radicals. Other anti-oxidant effects involve a role in the regeneration and protection of vitamin C and E. Anti-inflammatory activity has been demonstrated in vitro and in vivo in animals. Protection against UV-radiation-induced erythema was found in a clinical study following oral intake of PYC. In asthma patients symptom scores and circulating leukotrienes are reduced and lung function is improved. Immunomodulation has been observed in both animal models as well as in patients with Lupus erythematosus. PYC antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase. Dilation of the small blood vessels has been observed in patients with cardiovascular disease, whereas in smokers, PYC prevents smoking-induced platelet aggregation and reduces the concentration of thromboxane. The ability to inhibit angiotensin-converting enzyme is associated with a mild antihypertensive effect. PYC relieves premenstrual symptoms, including abdominal pain and this action may be associated with the spasmolytic action of some phenolic acids. An improvement in cognitive function has been observed in controlled animal experiments and these findings support anecdotal reports of improvement in ADHD patients taking PYC supplements. As an ingredient positively impacting circulation and the circulatory system, Pine Bark Extract works synergistically for supporting inner ear health.
[Int J Clin Pharmacol Ther. 2002 Apr;40(4):158-68. “A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.” Rohdewald P1.]

Melatonin
Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus. [Ann Otol Rhinol Laryngol. 2011 Jul;120(7):433-40. Melatonin: can it stop the ringing? Hurtuk A1, Dome C, Holloman CH, Wolfe K, Welling DB, Dodson EE, Jacob A.] . [“Tinnitus: Facts, Theories, and Treatments.” National Research Council (US) Committee on Hearing, Bioacoustics, and Biomechanics. Washington (DC): National Academies Press (US); 1982.]

Vitamin A
It is possible that people with dietary deficiencies of vitamin A do, in fact, realize both improvement in their hearing and reduction of tinnitus but that people with more normal diets cannot profit from increased intake of vitamin A. (A similar conclusion was reached by Ward and Glorig [1960] in a study of vitamin A and temporary threshold shift.) Because it is possible to overdose on vitamin A, it is not advisable for tinnitus sufferers to experiment with heavy doses of this agent without medical supervision. [“Tinnitus: Facts, Theories, and Treatments.” National Research Council (US) Committee on Hearing, Bioacoustics, and Biomechanics. Washington (DC): National Academies Press (US); 1982.]

Folate (as natural Folic Acid)
one nutrient commonly found deficient in those with hearing loss, especially the elderly who are often deficient in folacin as well as B12. When this happens, high levels of the toxin homocysteine form. This causes cholesterol deposits to build up on artery walls, reducing blood flow, nutrients, and oxygen to the heart and other organs, including the ears. Folacin supports energy production in hearing cells as well as increases circulation to the ears and elsewhere in the body. This deficiency is one of the main reasons people equate hearing loss with aging. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Vitamin D
As far as hearing is concerned, a deficiency in this vitamin has serious consequences and has been associated with otosclerosis (abnormal bone growth in the middle ear), unexplained and bilateral cochlear deafness, presbycusis, and sensorineural hearing loss. Researchers had to conclude that vitamin D deficiency is likely one of the causes and supplementation should be considered in persons with hearing loss. Vitamin D can be inhibited if there is also a magnesium deficiency. If there is a magnesium deficiency, this will also affect calcium intakes. As you can see, not just one nutrient can be isolated as being a cause or cure of something. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Vitamin E
Vitamin E is a powerful antioxidant that increases circulation, beneficial to all parts of the body including the ear. A deficiency has also been associated with such neurological dysfunctions as abetalipoproteinaemia (also known as Bassen-Kornzweig syndrome) and other fat absorption disorders. Fats, especially alpha-linolenic acid (ALA an Omega-3 essential fatty acid) are vital for the auditory brainstem responses. Furthermore, if the body has problems with fats, there will also be deficiencies in the vitamins stored in fats: vitamin A, vitamin E, and vitamin K, which will cause a domino-effect in health that can also affect hearing. Good circulation depends on a rich supply of essential fatty acids. Excess saturated fat in the diet can interfere with this, as has been shown in children with hearing fluctuations which varied according to their fat intake. Essential fatty acids also helps reduce the tendency to produce excessive amounts of earwax. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Iodine
Although iodine deficiency is most commonly associated with goiter (an overgrowth of the thyroid gland), studies in animals and humans have found that an iodine deficiency also plays a role in sensorineural hearing loss, including middle ear changes, cochlear lesions, congenital deaf-mutism and bilateral hearing deficits, as well as high hearing thresholds in children. Having an adequate dietary intake of iodine during pregnancy is critical for fetal brain development, beginning about the 14th week and continuing perhaps into the third trimester. In Guizhou, China noted improvements in hearing were seen in otherwise normal school children in iodine-deficient areas following use of iodized salt. There has also been a noted relationship between urinary iodine concentration and hearing capacity in children. Although iodine is available in ordinary salt, some iodine contents are deliberately lowered in some types of table salt in an effort to compensate for the excessive use of table salt by many persons. Certain medical conditions also require strict limitation of dietary salt, further reducing intake of iodine. However, it should be noted that not much is usually needed by the average person. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Manganese
Some nutritionists have noted a relationship between a deficiency in manganese and that of ear noises and diminished hearing. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

Glutathione
A deficiency of this amino acid can increase the risk of noise-induced hearing loss. Replenishing it reduces the damage. Another protective benefit is that it protects against gentamicin ototoxicity, which often induces damage to the cochlear. Studies have shown that aging causes a severe reduction in glutathione levels, especially in the auditory nerve. [PLoS One. 2009;4(6):e5987. Epub 2009 Jun 24. PMID: 20809938; Jan 01, 2009 Animal Study on Magnesium : CK(1213) : AC(132), Vitamin A : CK(420) : AC(66), Vitamin C : CK(1755) : AC(271), Vitamin E : CK(1417) : AC(250).]

†These statements have not been evaluated by the FDA. This Product is not intended to diagnose, treat, cure or prevent any disease.